The third regional Upper Indus Basin Network (UIBN) annual meeting convened on 22 February 2022 to assess the network’s overall progress, emerging challenges, and opportunities in the country chapters. UIBN members discussed strengthening regional cooperation for sustainable management of the basin and shared new and relevant research. The meeting was attended by the chair of the UIBN network, country chapter coordinators and co-coordinators from the four riparian countries, advisors, leads or co-leads of the Technical Working Groups (TWGs), experts from international organizations, and members from the secretariat (ICIMOD). The UIBN aims to strengthen upstream–downstream linkages and foster coordination and research related to climate, cryosphere, water, hazards and vulnerability, and adaptation.