The second Regional Upper Indus Basin Network (UIBN) Annual Meeting (RUAM) convened from 26-27 January 2021 to assess the network’s overall progress, and devise future strategies with focus on regional cooperation. The meeting was attended by the chair of the UIBN network, country chapter coordinators and co-coordinators from the four riparian countries, advisors, leads or co-leads of the Technical Working Groups (TWGs), experts from international organizations, and members from the secretariat (ICIMOD). The UIBN aims to strengthen upstream–downstream linkages, and foster higher coordination, and research related to climate, cryosphere, water, hazards and vulnerability, and adaptation.