Climate change in combination with socioeconomic processes and opportunities have an especially severe impact on people living in remote mountain areas of the Hindu Kush Himalaya. What is less well known is how changes in climate will affect in the quality of lives, livelihoods, and resources of diverse groups of people of the region. The chapter argues that it is not only important but also necessary to link climate science and climate interventions with relevant contextual experiences of the different groups of people due their differential experiences and vulnerabilities. The chapter provides illustrative cases studies to demonstrate the differential experiences and vulnerabilities of women and men as a result of the dynamics of gender relations in the context of climate change.