The International Centre for Integrated Mountain Development (ICIMOD) conducted the UIB-Network Workshop: Enhancing Science-based Regional Cooperation on 24-25 April 2018 in Kathmandu. Fifty-seven scientists and decision makers from the UIB region and beyond unanimously agreed to extend the UIB-N beyond Pakistan to form a regional UIB-N. Following this, the group revised the UIB-N core principles to make them more responsive across the transboundary river basin and modified the guidelines for the Technical Working Group, as well as Network Objectives, Vision, Mission, and governance structure. An Ad Hoc Regional Strategic Committee was formed during the workshop and is mandated to propose the governance framework of the Network within the six-month interim period. The expansion of the UIB-N into all four basin countries is expected to be an immense opportunity to learn best practices across borders, with the four country chapters as building blocks.