The Hindu Kush Karakoram Pamir Landscape (HKPL) represents a highly fragile alpine ecosystem with unique biodiversity that is facing equally unique threats. We have mounted a transboundary effort for long-term conservation and development that recognizes the shared histories, environments, struggles, and future of the landscape’s inhabitants. The initiative addresses cross-border challenges and opportunities in development and conservation across the Karakoram, Pamir Mountains, and the Wakhan along the China–Pakistan–Afghanistan–Tajikistan border area.