The fourth Regional Strategic Committee (RSC) meeting of the Upper Indus Basin Network (UIBN) was convened on 28 January 2021 to explore avenues for government ownership and sustainability of the UIBN and to discuss strategic guidelines for the country chapters focusing on the prevailing context and future needs. The meeting was attended by chair of the network; country chapter coordinators and co-coordinators from the four riparian countries (Afghanistan, India, China, and Pakistan); advisors; and members from the Secretariat (ICIMOD). The meeting covered discussions on the UIBN’S relevance, the network’s theory of change as a strategic roadmap, strengthening ongoing collaborations within the country chapters, and a sustainable way forward with government collaboration.