The cryosphere in the Himalaya-Karakoram (H-K) is widespread, and its services significantly affect the SDGs implementation in the region, in particular related to the ‘No poverty’ (SDG 1), ‘zero hunger’ (SDG 2), ‘good health and well-being’ (SDG 3), ‘work and economic’ (SDG 8) and ‘partnership for the goals’ (SDG 17). We here established the networks to illustrate the complex relationship of cryosphere services with national SDG priorities in the countries of H-K, including Afghanistan, Pakistan, India, China, Nepal and Bhutan. The cryosphere services contributing to the national SDG priorities and the key targets were elucidated in line with the centralities of the network. It was found that ‘freshwater’, ‘clean energy’, ‘runoff regulation’, ‘climate regulation’, ‘research and education’ and ‘infrastructure and engineering’ are the services that play critical roles in H-K, and they were then applied to assess the impact of cryosphere services on the national SDG priorities. We subsequently identified a set of principal indicators in relation to the key targets of national SDG priorities, which has the explanation up to 85% of six entry points (SEPs) to advance SDGs of each country in H-K. In conjunction with the centrality of the key targets to be contributed by the overall cryosphere services in the network for each country, the dependency of SEPs on the cryosphere services can be established through principal indicators in association with the national SDG priorities in H-K countries. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.