A sustainable hydropower development was developed by using the information entropy and the Brusselator principle and was applied to the hydropower data of China. Macro social economic and ecological environmental viewpoints were taken into account. The entropy change of each subsystem in a calendar year is analyzed to evaluate Chinese sustainable development capacity. It is found that the established model can effectively reflect the actual changes of sustainable development levels through the entropy change reaction system. Meanwhile, this model can demonstrate clearly how those indicators impact on the sustainable hydropower development and fill the absence of existing studies on sustainable hydropower development.