Present day land management approaches, especially those concerned with conservation, focus on achieving ecological resilience for natural resources and biological diversity, and socioeconomic resilience for the people who depend on the land for their livelihoods and wellbeing. Natural systems are highly complex and intricately interconnected. Therefore management approaches are becoming more holistic, taking into account the full range of functions of a large area of land or ‘landscape’ that contains a mosaic of interrelated ecosystems and is shaped by human use. In the Hindu Kush Himalayan region, landscapes often extend across national boundaries. Their effective management requires a common understanding, agreement, and cooperation among the countries that share the transboundary area, particularly in light of the impacts being experienced from a wide range of drivers of change, including climate change. This paper presents a framework for transboundary landscape management to support the development of ecological and socioeconomic resilience in the Hindu Kush Himalayan region, and describes a mechanism for implementing it. It gives examples of the application of the approach in several landscape areas selected by ICIMOD as pilot sites. A glossary of relevant terms is also provided. The paper will be of interest to policy makers, conservation and development practitioners, landscape and protected area managers, and institutions and researchers concerned with regional biodiversity conservation and management in the greater Himalayan region and beyond.