This study was carried out to explore the socio-cultural condition, knowledge and changing pattern for their environmental adaptation of Magar inhabitant at Bukini Tityang V.D.C. of western Nepal. There are 73 households make up a population of 450. The major subsistence activities of the local people are agriculture and animal husbandry. The economic condition of the majority of families is medium. Expenditure of the families has been at an increasing high rate which raises questions about the cohesive bond of their social structure. Out of the total population, 76.67% are literate, which is greater than national level. Young literate people do not have their applied knowledge in agricultural production and are also not attracted nor interested about it. Most people are aware of health and sanitation. Due to migration from different places, co-dominance has occurred between different clans. This phenomenon is not only in their cultural activities but also in the physical structure of the children. There are 86 plant species used to heal human and domestic animal diseases, 17 species for fodder, 14 species for making agricultural equipment, 25 species of wild fruits and 23 species used for different rituals and ceremonies. The elder Magars are rich in indigenous knowledge while the younger are not. If the older generation dies, their knowledge will vanished. The effect of modernisation and acculturation leads towards the increasing rate of dependency about food, clothing and recreation activities, which directly change the behaviour of the local people.