A total of 141 quadrats were sampled using stratified random sampling to study forest, environment and human interactions along an elevation gradient 1800 to 3665 m at the remote Kailash Sacred Landscape, Nepal. Eight forest types were identified, including Laurel-Oak to Rhododendron to Blue pine, comprising 191 species including 60 useful from 166 genera and 87 families. The environmental variables elevation, slope, and temperature were significant (p < 0.001) in determining the composition and distribution of forest types. Records of large numbers of useful plants along with diverse forest and vegetation types suggest a strong association between the culture of local villages and nature conservation. Due to changes in climate, socio-culture and land-use, forest degradation is expected to accelerate, thus forcing government and indigenous community forest management measures to acknowledge human, cultural and environmental variables for sustainable forest management.