As an informal knowledge and research network of national and international researchers working in the upper part of the Indus basin, the Upper Indus Basin Network (UIB-N) continually aims to coordinate research on climate, cryosphere, water, hazards and vulnerability, and adaptation-related issues. Accordingly, the International Centre for Integrated Mountain Development (ICIMOD) organized the Second Regional UIB-N Workshop on “Enhancing Science-Based Regional Cooperation” at its headquarters in Kathmandu, Nepal, on 17–18 January 2019. To further expand and strengthen the network’s activities in Afghanistan, a Side Event was organized on the second day of the UIB-N workshop: the Third Upper Indus Basin Network – Afghanistan Chapter (UIBN–AC) Meeting. The main objectives of this Afghanistan Side Event were to review the outcomes of the First UIBN–AC Meeting held in New Delhi in October 2018, discussing the progress made by the UIBN–AC’s Technical Working Groups (TWGs) and exploring the UIBN–AC’s next steps. The Side Event was organized by ICIMOD’s Strengthening Water Resources Management in Afghanistan (SWaRMA) Initiative and jointly implemented by the Governments of Australia and Afghanistan (Ministry of Energy and Water, MEW), ICIMOD, and the Commonwealth Scientific and Industrial Research Organisation (CSIRO).