The Upper Indus Basin Network (UIBN) was established in 2014 to promote coordination and collaboration among the organizations working in the member countries of the Upper Indus Basin (UIB) – Afghanistan, China, India, and Pakistan. The Second Regional UIBN Workshop was held in Kathmandu from 17–18 January 2019 by the Indus Basin Initiative (IBI) and Strengthening Water Resources Management in Afghanistan (SWaRMA) with support from the Department of Foreign Affairs and Trade (DFAT), Government of Australia, and the Swiss Agency for Development and Cooperation (SDC). The event brought together the Country Chapter (CC) members of the UIBN and expert civil society members and academics. The key objective of the workshop was to arrive at a consensus on the working principles of the UIBN in order to shape research and advocacy activities. Another important agenda was to decide upon the governance structure of the UIBN as recommended by the ad hoc strategic committee.