This document has been drafted as recommended during the Regional UIB-N Workshop held at the ICIMOD headquarters in Kathmandu on 24 and 25 April 2018. Learning from the success in Pakistan, the UIB-N has now been expanded to all the basin countries – Afghanistan, China, India, and Pakistan. This document describes the revised vision, mission, objectives, and governance framework of the network. It includes details on how the Regional UIB-N will function regionally as well as at the country level. It also defines the roles and responsibilities of the members and other operational mechanisms of the network in light of the discussions held during the Regional UIB-N workshop.