The Indus Basin plays a major role in the livelihood and well-being of nearly 268 million people. The people who live there are either directly or indirectly dependent on the water generated from the snow and glacier melt in the upstream part of the basin. The Indus Basin has become increasingly vulnerable due to climate change, as the basin flow is largely derived from snow and glacier melt, which are sensitive to changes in climate. Current and future water availability in the basin is therefore a critical aspect in the future planning and management of water resources as well as for preparing effective adaptation measures to cope with changing climate scenarios. This chapter reviews the literature on future climate projections in the Indus Basin based on climate modeling of the region. A majority of the studies reviewed project an increase in temperature that is more prominent in the higher altitude under high-emission scenarios. An increase in precipitation is projected in the Upper Indus Basin, with a decreasing trend in the Lower Indus Basin.