For many decades, non-timber forest products (NTFPs) have been an important livelihood commodity in Nepal as a traditional source of food, fiber, and medicines. However, the importance of NTFPs have been recognized only recently. NTFPs form more than 5% of Nepal’s national gross domestic product and are facing threat due to anthropogenic drivers and changing climate. Understanding of the current distribution and future dynamics of NTFPs is essential for effective conservation planning and management. In the maiden attempt, we used the Maxent model to understand the current and predict the future distribution by 2050 of 10 major NTFPs in Chitwan Annapurna Landscape, Nepal. The prediction accuracy of the models calculated based on the area under curve was high (>90%) and the prediction by 2050 highlights potential increase in distribution range of seven NTFPs and potential decrease in that of three NTFPs in the study area. The results from our study could play an important role in planning and management of these NTFPs considering their high economic and ecological significance and sensitivity to predicted climate change.