A regional orientation on long-term environmental and socio-ecological monitoring (LTESM) for transboundary landscapes in the Hindu Kush Himalaya (HKH) was conducted in Pokhara, Nepal, by International Centre for Integrated Mountain Development (ICIMOD) and Institute of Forestry (IoF)/ Tribhuvan University (TU) from 14 to 18 November 2016. Forty-eight participants representing four countries in the HKH — Bhutan, China, India, and Nepal — and four transboundary landscapes — Kangchenjunga Landscape (KL), Kailash Sacred Landscape (KSL), Landscape Initiative for Far Eastern Himalayas (Hi-LIFE), and Hindu Kush Karakoram Pamir Landscape (HKPL) — attended the workshop. The workshop objectives were to strengthen the capacity of partner institutions on LTESM and to develop a road map for conducting LTESM of priority ecosystems in transboundary landscapes. By bringing together relevant institutions from all KL member countries — Bhutan, India, and Nepal — this workshop also provided an opportunity to finalize and endorse the first two-year Knowledge Management and Community (KM&C) Strategy for Kangchenjunga Landscape Conservation and Development Initiative (KLCDI) — the KLCDI KM&C Strategy 2016–18.