Rapid advances in communication technology are making access to information faster, more reliable, and cheaper. At the same time, hydrological and meteorological monitoring technologies continue to improve significantly. These technological advances can be exploited to promote regional cooperation for flood risk reduction in the Hindu Kush Himalayas by providing an end-to-end flood information system. The system will function as a decision support tool for decision makers to alert vulnerable communities in a timely and accurate manner. This article provides an example of how regional cooperation has been achieved and is being promoted in the Hindu Kush Himalayas through the development of a regional flood information system.