The Hindu-Kush, Karakoram Himalaya (HKKH) region has a negative average glacial mass balance despite anomalous possible gains in the Karakoram. However, changes in climate may influence the mass balance across the HKKH. We use high resolution climate modelling to analyse the implications of unmitigated climate change on precipitation, snowfall, air temperature and accumulated degree days for the Hindu Kush, Karakoram, Jammu-Kashmir, Himachal Pradesh and West Nepal regions, and East Nepal and Bhutan. In our analysis we focus on the climate drivers of change rather than the glaciological response. We find a complex regional response to climate change, with possible increases in snowfall over the western HKKH and decreases in the east. Accumulated degree days are less spatially variable than precipitation and show an increase in potential ablation in all regions. Overall, the eastern Himalayan glaciers are expected to be most sensitive to climate change due to the decreases in snowfall and increased ablation associated with warming. The eastern glaciers are therefore projected to decline over the 21st century despite increasing precipitation. The western glaciers are expected to decline at a slower rate over the 21st century as a response to unmitigated climate compared to the glaciers of the east. Importantly, the glacier response depends on important glaciological factors, such as the extent of debris cover, which may be of critical importance in moderating the response to climatic change. Decadal variability has a large effect highlighting the need for long-term observation records to fully understand the impact of climate on the glaciers of the HKKH cryosphere. Spatial variability in projected snowfall patterns are likely to be a key driver of glacier mass balance over the 21st century. Importantly, the regional trends in snowfall do not necessarily follow the trends in precipitation. A key change in the HKKH cryosphere is a switch from snowfall to rainfall in the eastern Himalaya. Although glacial mass balance is likely to be sensitive to climate change, as overall precipitation is projected to increase this may lead to an overall increase in water resources. In the west, projections suggest that glacial mass balance could respond less to climate change than those in the east. However, projection uncertainty covers a small increase to a decrease in precipitation for the western HKKH and Indus basin and as a result the water resources of the highly populated Indus region may be more vulnerable to unmitigated climate change.