In this article, the author provides the first synthesis and classification of available environment-indicating proxies for lacustrine sediment. A review of spatio-temporal variations in lakes from the Tibetan Plateau, the dry areas of Northwestern China, the Yunnan-Guizhou Plateau and the plains of Eastern China since the LGM is then provided. The driving mechanism for variations in lake processes and characteristics is also discussed based on various temporal scales. The author then proposes that future investigations be conducted to: (1) strengthen the study of theoretics and interpretation of environment-indicating proxies, (2) enhance the study of high-resolution time series and spatial variability of lake environment evolution, (3) provide more attention on the influence of human activities on lake environments, and (4) boost construction of the Quaternary lake database of China.