The Kailash Sacred Landscape (KSL) spreads across a vast region that includes remote portions of the Tibet Autonomous Region of China and contiguous areas of Nepal and India. This area is historically, ecologically, and culturally interconnected; it is the source of four of Asia's most important rivers. At the heart of this landscape is the sacred Mount Kailash, revered by millions of people in Asia and throughout the world. The region and its people are highly vulnerable to climate change and environmental degradation, as well as threats associated with ongoing globalization processes and accelerating development. The Kailash Sacred Landscape Conservation and Development Initiative (KSLCDI) is a collaborative effort of the three neighbouring countries to help preserve the unique biological diversity, the many ecosystem goods and services, and the value-based cultural heritage of one of the most revered and sacred landscapes in the world. The present report is a synthesis of proposed activities based on a wide consultative process and national programme implementation plans submitted by partner institutions from each country. The Regional Programme Implementation Plan has been prepared for the five-year period 2012-2016 and describes how various programme elements will be implemented and executed in the KSL on a regional scale.