Earthquake disaster risk analyses provide significant scientific guidance for reducing earthquake disaster losses etc. The current commonly used method is based on the vulnerability of different types of buildings to evaluate, and may ignore the difference between the seismic resistance of the same type of buildings in different areas. The lethal level considers a series of reasons such as different types of buildings, resulting in different capacities for casualties, the lethal levels of the cities in the same subregion are considerably different and exhibit obvious distribution characteristics. In Yancheng and Suqian, the lethal levels in urban areas are lower than those in rural areas, but the lethal levels in Guangzhou show the opposite trend (the lethal levels are higher in urban areas than in other towns and rural areas). The average lethal level in Guangzhou is 0.3856, that in Suqian is 0.5844, and that in Yancheng is 0.5912. This study based on the lethal levels, conduct a comparative analysis of the earthquake disaster risk of cities throughout eastern China, and a map of the earthquake disaster risk in each city is obtained. The overall lethal level and risk in Guangzhou is much lower than those in Yancheng and Suqian. The main influencing factors in the different cities also diverge. One reason for the lower lethal levels and risk in Guangzhou is that most of the brick-concrete structures are equipped with ring beams and structural columns; conversely, Yancheng and Suqian exhibit higher lethal levels and risk because the brick-concrete structures have ring beams but no structural columns. These maps provide a technical reference and solid scientific and technological support for further earthquake disaster risk analyses and for disaster prevention, mitigation and disaster relief planning, and this method improves the accuracy of rapid postearthquake assessment. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.