A remote real-time monitoring system was developed for the remote real-time monitoring of mine slope deformation and internal forces. The system is based on cloud-computing technology and a 5S multimedia streaming monitoring data transmission system. It has now been applied to an open-pit iron mine in Nanfen to monitor the horizontal displacement of potential sliding surfaces. Compared with geometric monitoring methods in traditional geodetic surveying, the results show that this monitoring system has higher accuracy (0.01 mm) and the ability to monitor in real time for 24 h. These features can realize early warnings of mine slopes from multiple dimensions, and provide a guarantee for safe, continuous and the efficient production of mines. In addition, it can provide a certain reference for the prevention and control of mine slope disasters, and is beneficial to the application of information-based early warning technology. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.