Visualising the present biodiversity status of Nepal, an integrated approach comprising of biodiversity documentation, bio-prospecting, sustainable utilisation and conservation has become an urgent need. Realising the importance of medicinal plants altogether 45 plants were collected from Khumbu region with the altitudinal variation of 2582m to 4470m. Among the collected plant species 12 have been characterised as highly valuable. The important biochemical constituents and morphology of these plants have been described in this paper.