The international illegal trade in wildlife and wildlife products is one the major engines driving species to extinction. The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), which defines standards for use of wildlife and their products, represents a major global commitment to reverse this trend. It remains to be seen whether the terms of this treaty will be enforced. Focusing on Nepal and its neighbors, Aryal discusses the obstacles to its successful implementation: imprecise legislation, inconsistent policies, lack of coordination among relevant institutions (particularly, those responsible for regulating international trade), and the deadly threat posed by poachers determined to protect their endangered livelihoods. Aryal’s recommendations are detailed, far-reaching, and compelling.