The Khangchendzonga Biosphere Reserve (KBR) is one of the latest additions to the protected areas network in the Indian Himalayan Region. Located in the picturesque state of Sikkim in the eastern Indian Himalayan Region with snow-clad mountain peaks, numerous glaciers, a snow- and glacier-fed stream network and high-altitude lakes, this biosphere reserve (BR) is named after the world’s third highest mountain peak, Mt Khangchendzonga (8598 m), 1 of the 14 peaks in the world above 8000 m. The KBR covers an area of 2619.92 km2, 36.92% of the land area of Sikkim. BRs exemplify participatory sustainable resource use and ecosystem conservation. It is therefore important to consider the human dimensions of a BR from the outset and to survey stakeholders’ attitudes about conservation in order to take into account the inherent traditional dependence of people on forest-based resources. Potential future conflicts of interest need to be addressed through well–thought out strategies and integration of traditional conflict prevention mechanisms. Experience gained in the KBR may be useful in light of the widely reported conflicts in other BRs and protected areas around the world. Careful and informed planning may help reduce the likelihood of conflicts arising in newly established BRs.